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. 2017 Feb;56(2):152–159. doi: 10.1165/rcmb.2016-0272TR

Table 1.

Summary of Lung DC Subsets: Phenotypic Markers, Cytokine/Chemokine Production, and Expression of Key Chemokine Receptors

Lung DC Subset Markers (Human) Marker (Mouse) Cytokine/Chemokine Production Chemokine Receptors
cDC1

  • CD141+ (thrombomodulin, BDCA-3)

  • CLEC9A+ (DNGR-1, CD370)

  • Langerin(+/−) (CD207)

  • CD8α+

  • CD103+

  • Langerin(+/−)

  • IL-12, TNF-α

  • CCL5, CXCL10

  • XCR1 (61)

  • CCR6
cDC2

  • CD1c+ (BDCA-1)

  • SIRPα+ (CD172α)

  • CD11b+

  • SIRPα+ (CD172α)

  • IL-6, IL-12, IL-23, TNF-α

  • CXCL8, CXCL10

  • CCL3, CCL4, CCL5

  • CX3CR1 (61)

  • CCR6
pDC

  • CD303+ (BDCA-2)

  • CD304+ (Neuropilin-1, BDCA-4)

  • CD123+ (IL-3R)

  • Siglec-H+

  • Ly-6C+

  • BST2

  • Type I interferons

  • Multiple receptors expressed; see Reference 62

Definition of abbreviations: BDCA, blood dendritic cell antigen; BST, bone marrow stromal cell antigen; CCL, C-C motif chemokine ligand; CCR, C-C motif chemokine receptor; CD, cluster of differentiation; cDC, classical/conventional DCs; CLEC9A, C-type lectin domain family 9 member A; CXCL, C-X-C motif ligand; CX3CR1, C-X3-C motif chemokine receptor 1; DC, dendritic cell; DNGR-1, dendritic cell NK lectin group receptor 1; pDC, plasmacytoid DC; SIRPα, signal regulatory protein α; XCR1, X-C motif chemokine receptor 1.