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. 2018 Sep 17;7(18):e008604. doi: 10.1161/JAHA.118.008604

Figure 5.

Figure 5

ADAM23 inhibits activation of FAK‐dependent signaling pathways upon hypertrophic stresses. A, Representative Western blot and quantification results of the phosphorylation and total protein levels of MEK, ERK1/2, JNK1/2 and P38 in the hearts of AFMC, cADAM23‐KO, NTG and ADAM23‐TG mice 4 weeks after sham or AB surgery (n=4 mice per group). B, Representative Western blot and quantification results of the phosphorylation and total protein levels of FAK, AKT, GSK3β, m‐TOR in the indicated groups (n=4 mice per group). C, Representative results for Western blot of FAK and its downstream protein levels in NRCMs infected with AdshRNA, AdshADAM23, AdGFP or AdADAM23 treated with AngII or PBS. AB indicates aortic banding; FAK, focal adhesion kinase; NRCM, neonatal rat cardiomyocytes; NTG, nontransgetic.