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. 2018 Sep 15;7(18):e009379. doi: 10.1161/JAHA.118.009379

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© 2018 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Liraglutide treatment restores endothelial function and insulin response in endothelial cells from patients with diabetes mellitus (DM). Freshly endothelial cells isolated from patients with DM were treated with 0 or 10 nmol/L insulin for 30 minutes in the absence or in the presence of liraglutide and then fixed. Endothelial nitric oxide (eNOS) activation was evaluated as eNOS phosphorylation at Ser1177. Pooled data demonstrated that liraglutide restores insulin‐induced eNOS phosphorylation in endothelial cells isolated from patients with DM (n=10, *P=0.041; Cohen's d=0.752). Variables were compared using the paired t test.