Figure 5.

Liraglutide effect on endothelial function in diabetes mellitus (DM) is dependent on the glucagon‐like peptide 1 receptor (GLP‐1R). Venous endothelial cells from patients with DM were freshly isolated as described in the Materials and Methods section of this article and were treated with GLP‐1R antagonist, exendin fragment (9–39) (10 nmol/L, 30 minute), before the addition of liraglutide (100 nmol/L, 15 minutes) and insulin (10 nmol/L 30 minutes) sequential treatment. Pooled data demonstrated that exendin (9–39) impaired liraglutide‐driven restoration of insulin sensitivity in diabetic patients (n=5; *P=0.020; Cohen's d=1.676). Variables were compared using the paired t test.