Table 3.
Meta‐analytic Variant Associations With DBP Adjusted for Antihypertensive Medication Use8
| Race and Variant | LIFE Studies (n=1755) | Health ABC (n=788) | Meta‐analysis P Value | ||||
|---|---|---|---|---|---|---|---|
| β (SE) | P Value | MAF | β (SE) | P Value | MAF | ||
| White | |||||||
| m.15924A>G, tRNA‐thra | 2.85 (1.15) | 0.013 | 0.07 | 2.42 (1.51) | 0.007 | 0.21 | 0.0009 |
| Black | |||||||
| m.16172T>C, HVIb | 5.61 (2.01) | 0.006 | 0.13 | 5.95 (1.83) | 0.005 | 0.20 | 0.0003 |
| m.16189T>C, HVIb | 3.86 (1.38) | 0.005 | 0.50 | 5.73 (1.49) | 0.003 | 0.58 | 0.0002 |
DBP indicates diastolic blood pressure; Health ABC, Health, Aging, and Body Composition study; LIFE, Lifestyle Interventions and Independence for Elders studies; MAF, minor allele frequency; tRNA‐thr, threonine transfer RNA.
a
Variant not present in other race.
b
Variant present at MAF <5% but not significant in other race.