Table 4.
Race and Variant | LIFE Studies (n=1755) | Health ABC (n=788) | Meta‐analysis P Value | ||||
---|---|---|---|---|---|---|---|
β (SE) | P Value | MAF | β (SE) | P Value | MAF | ||
White | |||||||
m.15924A>G, tRNA‐thra | 3.64 (1.3) | 0.005 | 0.07 | 3.92 (1.74) | 0.008 | 0.21 | 0.0004 |
m.16069C>T, HVIa | −2.17 (1.07) | 0.043 | 0.11 | −2.72 (2.2) | 0.005 | 0.12 | 0.002 |
m.3197T>C, 16S rRNAa | 2.33 (1.23) | 0.060 | 0.08 | 4.39 (2.09) | 0.007 | 0.13 | 0.004 |
Black | |||||||
m.10586G>A, ND4La | −5.41 (2.61) | 0.039 | 0.09 | −5.22 (2.26) | 0.064 | 0.15 | 0.017 |
m.16172T>C, HVIb | 6.38 (2.16) | 0.003 | 0.13 | 8.11 (1.99) | 0.007 | 0.20 | 0.0002 |
m.16183A>C, HVIb | 7.63 (2.48) | 0.002 | 0.10 | 11.9 (2.53) | 0.003 | 0.11 | 0.00008 |
m.16189T>C, HVIb | 4.17 (1.48) | 0.005 | 0.50 | 6.68 (1.62) | 0.003 | 0.58 | 0.00018 |
m.93A>G, HV2a | 5.92 (2.27) | 0.010 | 0.12 | 6.92 (2.25) | 0.054 | 0.15 | 0.0046 |
Health ABC indicates Health, Aging, and Body Composition study; LIFE, Lifestyle Interventions and Independence for Elders studies; MAF, minor allele frequency; MAP, mean arterial pressure; rRNA, ribosomal RNA; tRNA‐thr, threonine transfer RNA.
Variant not present in other race.
Variant present at MAF <5% but not significant in other race.