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. 2018 Sep 11;7(18):e010009. doi: 10.1161/JAHA.118.010009

Table 4.

Meta‐analytic Variant Associations With MAP Adjusted for Antihypertensive Medication Use8

Race and Variant LIFE Studies (n=1755) Health ABC (n=788) Meta‐analysis P Value
β (SE) P Value MAF β (SE) P Value MAF
White
m.15924A>G, tRNA‐thra 3.64 (1.3) 0.005 0.07 3.92 (1.74) 0.008 0.21 0.0004
m.16069C>T, HVIa −2.17 (1.07) 0.043 0.11 −2.72 (2.2) 0.005 0.12 0.002
m.3197T>C, 16S rRNAa 2.33 (1.23) 0.060 0.08 4.39 (2.09) 0.007 0.13 0.004
Black
m.10586G>A, ND4La −5.41 (2.61) 0.039 0.09 −5.22 (2.26) 0.064 0.15 0.017
m.16172T>C, HVIb 6.38 (2.16) 0.003 0.13 8.11 (1.99) 0.007 0.20 0.0002
m.16183A>C, HVIb 7.63 (2.48) 0.002 0.10 11.9 (2.53) 0.003 0.11 0.00008
m.16189T>C, HVIb 4.17 (1.48) 0.005 0.50 6.68 (1.62) 0.003 0.58 0.00018
m.93A>G, HV2a 5.92 (2.27) 0.010 0.12 6.92 (2.25) 0.054 0.15 0.0046

Health ABC indicates Health, Aging, and Body Composition study; LIFE, Lifestyle Interventions and Independence for Elders studies; MAF, minor allele frequency; MAP, mean arterial pressure; rRNA, ribosomal RNA; tRNA‐thr, threonine transfer RNA.

a

Variant not present in other race.

b

Variant present at MAF <5% but not significant in other race.