Table 2.
Comparison of changes in protein abundance
| Gene Name | # of Total Spectral Counts | Fold Change by Quantitative SWATH-MS Analysis | ||
|---|---|---|---|---|
| AH (Drusen) |
AH (RPD) |
Comments | ||
| APOA1 | 300 | + 0.82 | + 1.28 | Drusen marker |
| APOA4 | 149 | + 0.22 | −0.53 | Lipid metabolism |
| CFHR2 | 10 | −1.20 | −0.92 | Lipid metabolism |
| CTSD | 101 | 0.00 | −0.53 | Autophagolysosomal |
| SERPINA4 | 46 | + 1.42 | + 3.82 | Antiangiogenesis |
| LUM | 39 | + 3.05 | + 4.54 | Extracellular matrix, Regulation of transcription |
| KERA | 3 | + 1.52 | + 1.48 | Extracellular matrix, Keratan (Cornea) |
| CLUS | 93 | −0.74 | + 0.25 | Clearance of cellular debris |
| PEDF | 407 | −1.36 | −0.07 | Neurotrophic property |
| PTGDS | 239 | −0.51 | −1.09 | Neuromodulator |
| TIMP1 | 20 | −0.88 | −1.06 | EMTa marker |
aEMT epithelial-mesenchymal transition