Effects of ASC sheet transplantation and/or treatment with irbesartan on systolic and diastolic blood pressures after MI. Systolic (A) and diastolic (B) blood pressures were measured 3 and 5 weeks after MI (2 and 4 weeks after ASC sheet transplantation) for the control MI hearts (MI, gray bars), and those treated with an ASC sheet alone (ST, blue bars), irbesartan alone (Irb, yellow bars) and both an ASC sheet and irbesartan (ST + Irb, green bars). The numbers of experiments are given in the parentheses (n = 3–5). *P < 0.05, **P < 0.01 (vs. control MI); ++P < 0.01, +P < 0.05 (vs. ST).