Table 2.
Comparisons of immune cell subsets between ESRD and controls
| Cell subset percentage | Healthy (57) | ESRD (412) | P value |
| CD4+ T cells | 62.8 (10.3) | 56.8 (13.3)↓ | 0.001* |
| Naïve T cells | 41.6 (15.6) | 28.5 (12.9)↓ | < 0.001* |
| Stem Memory T cells | 3.18 (2.01) | 7.50 (6.24)↑ | < 0.001* |
| Central Memory T cells | 30.7 (9.6) | 41.6 (11.1)↑ | < 0.001* |
| Effector Memory T cells | 27.0 (14.7) | 28.3 (12.9) | 0.47 |
| Terminally Differentiated T cells | 1.80 (2.24) | 2.36 (2.72) | 0.13 |
| CD8+ T cells | 26.5 (8.97) | 29.2 (10.1) | 0.051 |
| Naïve T cells | 32.9 (16.6) | 21.8 (16.1)↓ | < 0.001* |
| Stem Memory T cells | 4.78 (5.26) | 7.66 (6.20)↑ | 0.002* |
| Central Memory T cells | 6.30 (3.58) | 7.02 (7.91) | 0.50 |
| Effector Memory T cells | 29.1 (11.7) | 34.1 (16.6)↑ | 0.023* |
| Terminally Differentiated T cells | 32.9 (14.4) | 38.1 (16.7)↑ | 0.025* |
| Monocytes | |||
| Classical Monocytes | 64.1 (12.7) | 56.9 (11.7)↓ | < 0.001* |
| Intermediate Monocytes | 6.25 (4.91) | 10.1 (6.55)↑ | < 0.001* |
| Non-Classical Monocytes | 14.1 (10.8) | 19.9 (9.7)↑ | < 0.001* |
| Absolute cell number | Healthy (57) | ESRD (412) | P value |
| CD4+ T cells | 530 (307) | 523 (232)↓ | 0.02* |
| Naïve T cells | 247 (199) | 164 (112)↓ | < 0.001* |
| Stem Memory T cells | 17.2 (15.5) | 11.5 (9.1)↓ | < 0.001* |
| Central Memory T cells | 188 (114) | 229 (116) | 0.65 |
| Effector Memory T cells | 89.0 (49.5) | 120 (86.4)↑ | 0.006* |
| Terminally Differentiated T cells | 5.76 (7.59) | 9.25 (11.7) | 0.10 |
| CD8+ T cells | 277 (270) | 275 (180)↓ | 0.012* |
| Naïve T cells | 103 (97.7) | 54.5 (61.9)↓ | < 0.001* |
| Stem Memory T cells | 13.7 (17.6) | 4.63 (5.50)↓ | < 0.001* |
| Central Memory T cells | 11.6 (9.22) | 12.1 (13.9) | 0.47 |
| Effector Memory T cells | 92.9 (58.0) | 102 (83.6) | 0.26 |
| Terminally Differentiated T cells | 70.2 (53.9) | 105 (95.2)↑ | 0.013* |
| Monocytes | |||
| Classical Monocytes | 248 (91.2) | 264 (141) | 0.13 |
| Intermediate Monocytes | 19.2 (21.9) | 40.3 (33.9)↑ | 0.001* |
| Non-Classical Monocytes | 18.4 (12.0) | 56.3 (38.2)↑ | < 0.001* |
Percentages and absolute numbers (per μl blood) of naïve (TNAIVE), stem cell memory (TSCM), central memory (TCM), effector memory (TEM), terminally differentiated (TEMRA) subsets and three monocyte subsets (classical monocytes, intermediate monocytes, non-classical monocytes) were shown as mean (SD) and were compared between healthy controls and ESRD patients. The inter-group differences were analyzed by Student’s t-test
*P value < 0.05