Table 3.

Independent effects of age and dialysis vintage on immune cell aging

Cell Subset (percentage)	Age		Dialysis Vintage
	β	P value	β	P value
CD4+ T cells
Naïve T cells	−0.22	< 0.001*	0.20	0.095
Stem Memory T cells	0.08	0.029*	0.03	0.72
Central Memory T cells	−0.05	0.24	−0.60	< 0.001*
Effector Memory T cells	0.26	< 0.001*	0.41	0.001*
Terminally Differentiated T cells	0.02	0.12	0.02	0.46
CD8+ T cells
Naïve T cells	−0.56	< 0.001*	0.14	0.31
Stem Memory T cells	0.12	0.002*	0.001	0.91
Central Memory T cells	−0.01	0.61	0.11	0.16
Effector Memory T cells	0.16	0.014*	−0.67	< 0.001*
Terminally Differentiated T cells	0.42	< 0.001*	0.47	0.002*
Monocytes
Classical Monocytes	0.02	0.72	−0.32	0.005*
Intermediate Monocytes	−0.03	0.21	0.27	< 0.001*
Non-Classical Monocytes	−0.02	0.64	0.06	0.56

To separate the effects of age from dialysis vintage on immune changes, we tested the independent effects of age and dialysis vintage on cell subset percentages. In a multivariable-adjusted regression model (using subset percentage as the independent variable), the independent associations between immune cell percentage and age as well as the independent associations between immune cell percentage and vintage are shown

*P value < 0.05