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. 2018 Nov 1;9:2411. doi: 10.3389/fimmu.2018.02411

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Copyright © 2018 Gambineri, Ciullini Mannurita, Hagin, Vignoli, Anover-Sombke, DeBoer, Segundo, Allenspach, Favre, Ochs and Torgerson.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) CD25+FOXP3+ expression in IPEX, IPEX-like patients and control subjects. (B) IPEX patients differ according to the type of FOXP3 mutations. Deletion = in frame deletion; frameshift = deletion with frameshift. Values are expressed as percentage of CD4 cells, median and 5–95 percentile are shown, circles, triangles, and cones represent singles patients out of 5–95 percentile (circles = IPEX patients, triangles = IPEX-like patients, cones = control subjects) (^**p < 0.001; ^***p < 0.0001).