Extended Data Figure 6 |. Sequence alignment of TERT with secondary structure assignments based on known structures.

a, Sequence alignment of Tetrahymena and human TEN domains. The secondary structure assignments of the Tetrahymena TEN domain³⁴ (PDB 2B2A) are shown above the aligned sequences. Regions removed prior to fitting are indicated with dashed lines below the sequences. b, Sequence alignment of the Tribolium, human and Tetrahymena TERT, with the latter two N-terminally truncated to match Tribolium. Secondary structure assignments of the Tribolium TERT are shown on top, with conserved motifs labeled in blue. Throughout the figure, the η symbol refers to a 3₁₀-helix. Strict β-turns and strict α-turns are displayed as TT and TTT. The three catalytic aspartic acids are indicated with black arrowheads. ESpript was used to generate this figure⁷⁶.