Figure 5:

Spatial reference memory performance on Morris water maze and behavior in the open field. Latency (s) of control mice (black), binge-ethanol (red), varenicline (blue) and varenicline-ethanol treated (green) during cue trials in the water maze (A), latency (s) during training trials over 6 days (B) and thigmotaxis (% time spent in the outer 10% of the tank during training) (C). In (D), total distance travelled (cm) in the open field, average speed (cm/s) in (E) and average time spent in the center during 5 minutes in the open field (F). Data are mean ± S.E.M. Significance in ANOVA (p < 0.05) is demonstrated by *.