Table 2.
MCF10A GEPs IPA analysis
| IPA analysis of GEP IR induced in MCF7 breast cancer cell line | |||||
| Type of radiation treatment (particle type) | Top canonical pathway | enes involved | p-value | Overlap | % |
| e- | Cell cycle control of chromosomal replication | CDC6; CDC45; CDK6; MCM2;MCM4; MCM6; MCM7; ORC1;ORC6; POLA2; POLE; PRIM1; PRIM2; RPA4 |
2.63E-05 | 14/38 | 36.8 |
| p53 signaling | APAF1; ATM;BAX; BBC3;BRCA1; CDKN1A; CHEK1; DRAM1; FAS;GADD45A1; GADD45B; IRS1; MDM2; PIK3C2B; PIK3R3; PIK3R5; PML; PRKDC; SERPINB5; SNAI2; TIGAR; TLR9; TNFRSF10B; TP53I3; TP53INP1; TRIM29 |
1.35E-04 | 26/111 | 23.4 | |
| Role of macrophages, fibroblasts and endothelial cells in rheumatoid arthritis | ATM; CALML5; CCL5; CEBPB; CEBPD; DAAM1; DKKL1; FN1; FOS; FZD2; FZD6; PZD7; GNAO1; ICAM; IL6; IL15; IL1RN; RAK4; IRS1; LEF1; LRP1; LTB; MAPK9; NFAT5; NFATC2; NFATC4NFKBIA; NGFR; PDGFA; PIK3R3; PIK3R5; PLCB3; PLCD4; PLCG2; PPP3R1; PRKCZ; PRKD3; RYK; SOCS1; SOCS3; TCF7L1; TCF7L2; TLR2; TLR9; TNF; TNFRSF11B; WNT4; WNT6; WNT5B |
1.28E-03 | 50/296 | 16.9 | |
| Renin-angiotensin signaling | ADCY4; ADCY5; AGTR1; ATM; CCL5; FOS; IRS1; ITPR1; MAP3K1; MAPK9; PMAPK13PIK3C2B; PIK3R3; PIK3R5; PLCG2; PRKAR2A; PRKAR2B; PRKD3; PTGER2; SHC2; SHC3; TLR9; TNF; |
2.27E-03 | 24/119 | 20.2 | |
| Netrin signaling | ABLIM3; ENAH; NFAT5; NFATC2; NFATC4; NTN1; PPP3R1; PRKAR2A; PRKAR2B; RAC2; RYR1 |
2.45E-03 | 11/39 | 28.2 | |
| p+ | p53 signaling | BBC3; CDKN1A; FAS; GADD45A; MDM2; PIK3CD; PIK3R5; SNAI2; TIGAR; TLR9; TNFRSF10B; TP53INP1 |
4.80E-07 | 10.8 | 12/111 |
| MSP-RON signaling pathway | ACTA1; ACTA2; ITGAM; PIK3CD; PIK3R5; TLR9 |
5.25E-04 | 10.2 | 6/59 | |
| PEDF signaling | DOCK3; FAS; PIK3CD; PIK3R5; SERPINF1; SRF; TLR9 |
6.18E-04 | 8.3 | 7/84 | |
| Paxilin signaling | ACTA1; ACTA2; ITGAM; ITGAX; PIK3CD; PIK3R5; SOS1; TLR9 |
6.40E-04 | 7.3 | 8/110 | |
| Fak signaling | ACTA1; ACTA2; CAPN8; PIK3CD; PIK3R5; SOS1;TLR9 |
1.54E-03 | 7.1 | 7/98 | |
| e-/p+ (common genes) | p53 signaling | BBC3; CDKN1A; FAS; GADD45A; MDM2; PIK3R5; SNAI2;TIGAR; TLR9;TP53INP1 |
5.56E-09 | 9 | 10/111 |
| Melanoma signaling | CDKN1A; MDM2;PIK3R5; TLR9 | 5.93E-04 | 7.3 | 4/55 | |
| PEDF signaling | FAS; PIK3R5; SERPINF1; TLR9; | 2.87E-03 | 4.8 | 4/84 | |
| Hereditary breast cancer signaling | CDKN1A; GADD45A; PIK3R5; SMARCA2;TLR9 |
2.96E-03 | 3.6 | 5/139 | |
| Role of p14/P19arf in tumor suppression | MDM2; PIK3R5;TLR9 | 3.16E-03 | 7.1 | 3/42 | |
GEP, gene expression profile; IPA, Ingenuity pathway analysis; IR, ionizing radiation.