Table 5.

Top-5 statistically relevant pathways of the selected gene signatures

		Pathway name	Genes found in GEP list	Entities (total)	p-value
MCF10A 81-gene signature	1	Mineralocorticoid biosynthesis	2	20	7.89E-3
2	Glucocorticoid biosynthesis	2	23	1.03E-2
3	Androgen biosynthesis	2	27	1.4E-2
4	Regulation of IFNA signaling	2	28	1.49E-2
5	Interleukin-7 signaling	2	31	1.81E-2
MCF7 141-gene signature	1	Transcriptional regulation by TP53	22	486	4.11E-8
2	TP53 regulates transcription of cell death genes	8	83	5.88E-6
3	Transcriptional activation of p53 responsive genes	3	6	0.00005
4	Transcriptional activation of cell cycle inhibitor p21	3	6	0.00005
5	TP53 regulates transcription of death receptors and ligands	4	18	0.00006
MDA-MB-231 154-gene signature	1	Histone acetyltrasferases (HATs) acetylate histones	6	110	1.68E-3
2	RUNX1 regulates transcription of genes involved in B cell Receptor (BCR) signaling	2	7	2.95E-3
3	Arginine methyltransferase (RMTs) methylate histone arginines	4	53	3.24E-3
4	Metalloprotease Deubiquitinating enzymes (DUBs)	3	32	5.93E-3
5	Histone deacetylase (HDACs) deacetylate histones	4	63	5.94E-3

GEP, gene expression profile.