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mi/siRNAs-guided target cleavage. Mature miRNAs and siRNAs can guide AGO2 to cleave perfect complementary mRNA targets. Cleavage of targets occurs between the nucleotides that pair with the 10th and 11th position of the mi/siRNA. This leave a 3′hydroxyl (OH) and 5′monophosphate(P) at the cleaved termini. These cleaved mRNAs the are rapidly destroyed by exonucleases.
