Fig. 4.

The effects of oxime RS194B (administered intramuscularly) on AChE/BChE activities in whole blood and brain of sarin- or VX-exposed mice at 0.5, 1, 3, and 6 hours after treatment. Activities are expressed as the median and interquartile range of four values obtained for each mouse and sample and compared with the control group (100% value). The control group received 2 ml/kg saline i.m. Open squares indicate mice that were exposed to 0.75 LD₅₀ of sarin or VX subcutaneously. Solid circles indicate mice that were exposed to the same dose of sarin or VX and 1 minute after exposure to OP received RS194B (125 mg/kg with atropine 10 mg/kg, i.m.). Statistical significance between mice that received RS194B and atropine therapy was determined using t tests (two-sided, with 95% confidence interval). Differences were considered significant when *P < 0.05; **P < 0.005; ***P < 0.001.