Table 2.

Univariate Cox proportional hazards model for DFS and OS. *p < 0.05 indicates a significant association among the variables. HR, hazard ratio.

	DFS			OS
	HR	95% CI	p-value	HR	95% CI	p-value
age, years
<65	—			—
≥65	1.009	0.659–1.841	0.714	0.934	0.530–1.644	0.822
AJCC stage
I	—			—
II	1.108	0.305–4.027	0.877	0.667	0.201–2.215	0.518
III	6.823	2.097–22.199	0.001*	3.401	1.184–9.771	0.026*
IV	49.185	12.615–191.764	<0.001*	40.074	11.257–142.668	<0.001*
differentiation
high	—			—
moderate	1.315	0.750–2.306	0.341	1.458	0.764–2.780	0.273
low	3.577	1.885–6.786	<0.001*	4.358	2.140–8.872	<0.001*
vascular invasion
yes	4.901	2.469–9.721	<0.001*	4.638	2.152–9.997	<0.001*
no	—			—
miR-125a-5p
high	—			—
low	6.118	3.004–12.462	<0.001*	6.348	2.875–14.014	<0.001*