Figure 6.

Glimpses of crosstalk in broader physiological context. (a) In the absence of HS, RPTPσ favours trans-synaptic binding and synaptic signalling with TrkC. In the presence of HS, RPTPσ–TrkC interaction is disrupted and RPTPσ clustering and neuronal outgrowth are promoted. (b) The extracellular matrix protein Tsp1 binds a variety of proteins and receptors in the absence of HS, including FGF. HS mediates Tsp1 clustering and other Tsp1 interactions, including release of FGF from Tsp1 and formation of the FGF–FGFR signalling complex.