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. 2018 Nov 1;9:2675. doi: 10.3389/fmicb.2018.02675

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Copyright © 2018 Suwal, Wu, Liu, Liu, Sun, Liang, Gao, Zhang, Kou, Liu, Wei, Wang and Zheng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effectiveness of the probiotic B. longum JDM 301 is not related to colitis severity or high-fat diet. (A) PCoA analysis illustrating the presence of different microbial community between HFD-fed mice from cohort (A,B). Each symbol represents one individual mouse. The HFD fecal bacterial samples were collected 6 weeks after HFD and before probiotic and DSS treatment. (B) Schematic diagram for experimental design. (C) Body weight changes during DSS treatment in indicated mice. (D) Survival curve. (E) Representative images of H&E stained distal colon tissues from indicated mice (magnification: 200×). (F) Histologic scores. All data are given as means ± SEMs. ^∗P < 0.05; ^∗∗P < 0.01; ^∗∗∗P < 0.001. The number of mice per group was 3∼6.