Fig. 3.

(A) Nocardiopsistin PKS genes are highly homologous to other angucyclines, such as landomycin pathway (lan, accession #AF080235), oviedomycin pathway (ovm, accession #AJ632203); and urdamycin pathway (urd, accession #X87093). The number in parentheses indicates sequence identity between nocardiopsistin genes with its corresponding homologous genes. The conserved gene (empty arrows) encoding a C9 reductase often present in angucycline pathways is also included. (B) Illustration of the in-frame deletion of nocardiopsistin PKS genes in HB-J378 using double crossover.