Figure 2.

Cpd A in K/BxN serum transfer arthritis. Arthritis was induced by i.p. injection of 150 μL K/BxN serum on days 0 and 2 of the experiment. 50 mg/kg body weight cpd A or vehicle control was daily administered p.o. by gavage starting 2 days prior to the first application of K/BxN serum (day −2). The course of arthritis was evaluated by determining (A) the clinical arthritis score and (B) ankle thickening at the hindpaws. (C) Typical clinical presentation at the hindpaws on day 10 of the experiment. (D) Representative histopathologies of the hindpaws on day 10 presenting with leukocyte infiltrates, synovial fibroblast hyperplasia, and bone and cartilage erosions. The presented are merged from two independent experiments with 10 mice per group in total. All results are presented as mean ± SEM. Results in (A) and (B) were tested for statistical significance by two‐way