Table 3.

Distinguishing Brain Lesions on MRI between NMOSD and MS

Neuromyelitis optica spectrum disorder (NMOSD)	Multiple sclerosis (MS)
Lesion intimately adjacent to lateral ventricle extending along the length of corpus callosum	Lesions oriented perpendicular to lateral ventricle (Dawson’s fingers)
Large, oedematous, heterogeneous “marbled” callosal lesions	Lesions located at inferior callosal margin or callosal-septal surface
Large, confluent hemispheric lesions	Discete, ovoid lesions
Lesions adjacent to lateral, third and fourth ventricles along the ependymal lining	Lesions adjacent to lateral ventricle in inferior temporal lobe
Long, contiguous CST lesions	Juxtacortical U-fibre lesions
Cortical lesions rare	Cortical lesions
Perivenous lesions less common	Perivenous lesions common
Clinically silent lesions less likely	Clinically silent lesions more likely

CST, corticospinal tract; MS, multiple sclerosis; NMOSD, neuromyelitis optica spectrum disorder.