Table 3.

Diagnostic performance for the detection of PZ prostate cancer stratified by presence of hemorrhage

	Reader 1			Reader 2
Present hemorrhage	Absent hemorrhage	p value	Present hemorrhage	Absent hemorrhage	p value
AUC	0.77 (0.68–0.84)	0.85 (0.79–0.90)	0.088	0.69 (0.59–0.76)	0.78 (0.62–0.78)	0.107
Sensitivity	0.55 (0.43–0.67) [37/67]	0.75 (0.66–0.82) [91/122]	0.005	0.39 (0.27–0.52) [26/67]	0.79 (0.68–0.87) [86/122]	<0.001
Specificity	0.89 (0.78–0.96) [49/55]	0.85 (0.75–0.92) [68/80]	0.503	0.89 (0.78–0.96) [49/55]	0.79 (0.69–0.87)[63/80]	0.129
Positive predictive value	0.86 (0.74–0.93) [37/43]	0.88 (0.82–0.93) [91/103]	0.741	0.81 (0.66–0.91) [26/32]	0.84 (0.77–0.89) [86/103]	0.692
Negative predictive value	0.62 (0.55–0.68) [49/79]	0.69 (0.61–0.75) [68/99]	0.329	0.54 (0.49–0.60) [49/90]	0.64 (0.57–0.70) [63/99]	0.163

Data are 95% Cis in parentheses and numerators and denominators in brackets.