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. 2018 Nov 2;10:5261–5271. doi: 10.2147/CMAR.S174066

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© 2018 Wu et al. This work is published and licensed by Dove Medical Press Limited

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The effect of HOTAIR on autophagy in PC cells.

Notes: (A, B) The expressions of LC3-I and LC3-II were detected by Western blot when PC cells were transfected with pcDNA3.1 or pcDNA3.1-HOTAIR and treated with bafilomycin to detect autophagy flux. (C, D) Using pGFP-LC3 to detect the LC3 expression when PC cells were transfected with pcDNA3.1 or pcDNA3.1-HOTAIR under fluorescence microscope. (E) Transmission electron microscopy showed autophagosome formation was detected in PC cells transfected with pcDNA3.1-HOTAIR. (F) The number of autophagosomes was counted in pcDNA3.1 and pcDNA3.1-HOTAIR group; *P<0.05.

Abbreviations: LC3, microtubule-associated protein 1 light chain 3; HOTAIR, HOX transcript antisense RNA; PC, pancreatic cancer.