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A computational tool to design the spacer size of bivalent ligands. (A) Computational model of the μ–δ heterodimer bound to MDAN-21, the two pharmacophore units (OXY and NTI, respectively) are shown in magenta spheres, carbon spacer is grey. (B) The preferred solution from the computational tool showing the spacer optimally placed across the protein van der Waals surface and connected to each ligand
