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. 2018 Nov 2;11:7795–7803. doi: 10.2147/OTT.S178152

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© 2018 Tian et al. This work is published and licensed by Dove Medical Press Limited

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PTPRF is downregulated in gastric adenocarcinoma tissue.

Notes: (A) Real-time PCR quantification of PTPRF mRNA levels in gastric adenocarcinoma tissue and matched adjacent nontumoral tissue (n=27). The mRNA expression of PTPRF in gastric adenocarcinoma tissue was significantly lower than in nontumoral tissue. (B) PTPRF showed a lower protein level in MKN45 tumor cells than normal GES1 epithelial cells. (C) Effect of PTPRF mRNA level on the overall survival of gastric adenocarcinoma patients (data generated from Cancer Genome Atlas database), showing its possible antitumor roles. Representative immunohistochemistry (IHC) results of PTPRF protein expression in adjacent nontumoral tissue (D) and gastric adenocarcinoma tissue (E), showing positive staining in both nucleus and cytoplasm. (F) Representative high expression of PTPRF in gastric adenocarcinoma tissue (IHC score 12). *P<0.05 (paired Student’s t-test); bar 100 µm.