Table 3.
Multivariable logistic regression analyzing intensive care unit mortality and the longest episode of hypotension time below threshold of 65 mmHg
| Parameter | Estimate | Standard error | Wald Chi-square | Pr > ChiSq | Odds ratio |
|---|---|---|---|---|---|
| Intercept | − 3.39 | 0.23 | 219.19 | < 0.0001 | 0.03 |
| MAP at initiation of vasopressors (vs. ≥ 65 mmHg) | |||||
| < 65 mmHg | 0.15 | 0.07 | 4.29 | 0.0384 | 1.16 |
| Missing | − 0.36 | 0.16 | 5.10 | 0.024 | 0.70 |
| Longest episode with MAP < 65 mmHg (vs. never below), hours | |||||
| > 0 to < 2 | 0.57 | 0.20 | 7.88 | 0.005 | 1.76 |
| ≥ 2 to < 4 | 0.66 | 0.20 | 10.38 | 0.0013 | 1.93 |
| ≥ 4 to < 6 | 0.80 | 0.21 | 14.19 | 0.0002 | 2.23 |
| ≥ 6 to < 8 | 1.06 | 0.23 | 22.15 | < 0.0001 | 2.90 |
| ≥ 8 to < 10 | 1.24 | 0.25 | 25.04 | < 0.0001 | 3.44 |
| ≥ 10 to < 12 | 1.47 | 0.27 | 29.19 | < 0.0001 | 4.36 |
| ≥ 12 to < 16 | 1.67 | 0.26 | 40.46 | < 0.0001 | 5.30 |
| ≥ 16 to < 20 | 1.70 | 0.32 | 27.87 | < 0.0001 | 5.47 |
| ≥ 20 | 1.96 | 0.28 | 49.20 | < 0.0001 | 7.10 |
| Max catecholamine dose (vs. 0 to < 0.2), NED | |||||
| ≥ 0.2 to < 0.5 | 0.64 | 0.09 | 50.58 | < 0.0001 | 1.89 |
| ≥ 0.5 to < 1.0 | 1.44 | 0.10 | 195.55 | < 0.0001 | 4.24 |
| ≥ 1.0 to < 1.5 | 1.85 | 0.14 | 174.34 | < 0.0001 | 6.37 |
| ≥ 1.5 to < 2.0 | 2.07 | 0.24 | 73.03 | < 0.0001 | 7.95 |
| ≥ 2.0 to < 2.5 | 2.08 | 0.31 | 45.37 | < 0.0001 | 7.97 |
| ≥ 2.5 | 1.61 | 0.20 | 63.21 | < 0.0001 | 4.99 |
| Age (vs. < 65), years | |||||
| 65–74 | 0.33 | 0.09 | 12.48 | 0.0004 | 1.39 |
| 75–84 | 0.48 | 0.09 | 28.23 | < 0.0001 | 1.62 |
| ≥ 85 | 0.73 | 0.11 | 44.40 | < 0.0001 | 2.07 |
| Female (vs. male) | − 0.07 | 0.07 | 0.92 | 0.3364 | 0.94 |
| Severe sepsis/septic shock (vs. none) | − 0.19 | 0.08 | 5.44 | 0.0197 | 0.83 |
| SOFA score (vs. ≤ 4) | |||||
| > 4 to ≤ 6 | 0.03 | 0.11 | 0.07 | 0.7851 | 1.03 |
| > 6 to ≤ 8 | 0.09 | 0.11 | 0.58 | 0.4447 | 1.09 |
| > 8 to ≤ 10 | 0.32 | 0.12 | 6.75 | 0.0094 | 1.37 |
| > 10 | 1.09 | 0.12 | 83.90 | < 0.0001 | 2.98 |
| Hypertension (vs. none) | − 0.02 | 0.08 | 0.09 | 0.7674 | 0.98 |
| Baseline mechanical ventilation (vs. none) | 0.15 | 0.07 | 4.45 | 0.035 | 1.16 |
| Baseline continuous renal replacement therapy (vs. none) | 1.26 | 0.38 | 11.19 | 0.0008 | 3.54 |
| Albumin level (vs. ≥ 2.5 g/dL) | |||||
| < 2.5 g/dL | 0.60 | 0.11 | 29.41 | < 0.0001 | 1.83 |
| Missing | 0.18 | 0.08 | 5.01 | 0.0252 | 1.20 |
| Creatinine level (vs. < 2.0 mg/dL) | |||||
| ≥ 2.0 mg/dL | − 0.09 | 0.08 | 1.14 | 0.2863 | 0.92 |
| Missing | − 0.55 | 0.17 | 10.07 | 0.0015 | 0.57 |
| Lactate level (vs. < 2.0 mmol/L) | |||||
| ≥ 2.0 mmol/L | 0.38 | 0.08 | 20.66 | < 0.0001 | 1.46 |
| Missing | 0.37 | 0.10 | 14.90 | 0.0001 | 1.45 |