Fig. 2.
Transcriptome assessment suggests altered signaling pathways in Gaa−/− cervical spinal tissues. Total gene changes based on age-genotype interaction analysis are summarized in A. The top 10 upregulated Kyoto Encyclopedia of Genes and Genomes (KEGG) (B) and Canonical (C) pathways show signaling changes related to the lysosomes, inflammation, and cell death. The top 10 downregulated KEGG (D) and Canonical (E) signaling pathways reveal decreases in neuronal signal transduction, long-term potentiation (LTP), and similarities to other diseases. Enriched signaling pathways are graphed as the negative log10 of their P value. Statistical significance was set to a false discovery rate (FDR) q value of <0.05.