Fig. 6.

mRNA changes indicate altered cell metabolism and signal transduction in Gaa^−/− cervical spinal cord. Genes related to cell metabolism and signal transduction were dysregulated in Gaa^−/− tissues (A). B and C: the top 10 up- and downregulated biological processes, respectively. D: further shifts in cell metabolism. There was also clear evidence for downregulation of genes related to excitatory neural transmission (E). Enriched signaling pathways are graphed as the negative log₁₀ of the P value. Statistical significance was set to an FDR q value of <0.05.