TABLE 1.

Free serum and tissue linezolid concentrations and lung to serum drug concentration ratios among patients with drug-resistant pulmonary tuberculosis

Patient	Dose mg·kg−1	Free serum concentration at time of resection# μg·mL−1	Non-diseased lung tissue concentration μg·mL−1	Diseased lung tissue concentration μg·mL−1	Diseased lung/serum	Non-diseased lung/serum
1	9.23	7.73	10.24	7.09	0.92	1.32
2	11.54	10.06	4.27	6.60	0.66	0.42
3	8.33	8.79	3.43	4.27	0.49	0.42
4	7.50	7.24	2.03	1.30	0.17	0.27
5	7.69	7.71	6.01	4.22	0.55	0.78
6	6.19	3.68	1.17	0.81	0.22	0.32
7	8.33	5.87	1.25	2.91	0.50	0.21
8	10.53	10.54	4.97	2.75	0.26	0.47
Median	8.33	7.77	3.85	3.56	0.49	0.41

^#: free serum concentration=measured linezolid concentration×0.69.