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Binding of CAY10471 and fevipiprant. (A) Ligand binding pocket with the open end and the distal end and binding poses of both ligands. (B) Residues involved in the binding of fevipiprant and CAY10471. Hydrogen bonds are shown as black dashed lines. Disulfide bonds are shown as yellow sticks. (C) Different conformations of W2837.32 and L20 in the structures of CRTH2 with two ligands. The disordered region between L20 and A25 in CRTH2-CAY10471 is shown as a slate dashed line.
