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. Author manuscript; available in PMC: 2019 Sep 15.
Published in final edited form as: Neuropharmacology. 2018 Aug 4;140:150–161. doi: 10.1016/j.neuropharm.2018.08.003

FIGURE 4:

FIGURE 4:

Effects of GW0742 treatment on brain atrophy and hippocampal morphology at 4 weeks post hypoxia-ischemia (HI). (A-B) Significant loss of right-to-left hemisphere (ipsilateral/contralateral) weight ratio is evident in vehicle rats, and which was significantly improved by GW0742 treatment at 4 weeks post HI. (C-D) Representative pictures of Nissl's stained brain slices showed tissue loss in ipsilateral hemisphere. GW0742 treatment significantly reduced the percent of tissue loss when compared with vehicle. (E) Representative images of hippocampus in ipsilateral hemisphere. HI resulted in degeneration of ipsilateral hippocampus, while GW0742 attenuated hippocampal damage. *p < 0.01 vs. sham; #p < 0.05 vs. HI+vehicle. n = 9 for sham and HI+ GW0742, n=8 for HI+vehicle group.