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. 2018 Oct 4;38(8):1539–1550. doi: 10.1007/s10571-018-0622-5

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 4 — No difference in tagged versus untagged tau in EV fractions. In order to investigate whether also tau is differentially processed via EVs when modified, cells were transfected with either tau or tau:GFP. a Absolute levels of tau in EVs, b FFP, and c IC fractions, as measured by ELISA. d Percentage of tau in EVs compared to FFP fractions. e Percentage of tau in EVs compared to IC fractions. f Percentage of tau in FFP compared to IC fractions. In contrast to α-syn, the relative distribution of tau did not change when the GFP tag was present. Lysis of the vesicles significantly increased the levels of tau, indicating a large portion of the protein inside the EVs. Bars represent mean ± SD, n = 3. A t test was used to determine the significance between the two constructs (*p < 0.05, **p < 0.01, ***p < 0.001)