| Box 1. Questions for future research |
| • Do changes in CBIR density after abstinence from cannabis parallel changes in target receptors of other drugs of abuse? |
| • Are behavioral and mood variations associated with cannabis use a risk factor or consequence of cannabis addiction? |
| • Are long-term behavioral and neurophysiological changes related to the THC content in cannabis? |
| • Is cannabis use associated with long-term changes in glutamate signaling as seen in other drugs of abuse? |
| • Is cannabis use associated with disruptions in the amygdala and habenula as seen with other drugs of abuse? |
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