Table 2.
Effect of selected stabilizing ligands on the characteristics of curcumin nanoparticles prepared by antisolvent precipitation
| Ligand | Size (nm) | Polydispersity index (PDI) | ζ-potential (mV) | Curcumin (µM)a | Stability (days)b |
|---|---|---|---|---|---|
| None (control) | 1187 ± 97 | 0.456 | −18.2 ± 2.6 | NA | NA |
| Proline | 229 ± 62 | 0.207 | −39.1 ± 2.9 | 860 | 2 |
| Tannic acid | 283 ± 71 | 0.274 | −30.3 ± 4.1 | 1,400 | 7 |
| Polyvinylpyrrolidone | 175 ± 41 | 0.188 | −2.2 ± 4.3 | 1,300 | 12 |
| Polyquaternium-10 | 223 ± 54 | 0.081 | +38.4 ± 3.2 | 1,200 | 16 |
a Maximal curcumin concentration reached in stable aqueous dispersion
b Storage duration of homogenous aqueous dispersion without visible separation