Table 3.
Mean medications over time: all eyes and low- and high-IOP subgroups
| All eyes (n = 53) | Baseline IOP ≤ 23 mmHg (n = 28) | Baseline IOP > 23 mmHg (n = 25) | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Mean medication (n) ± SEa | Mean difference (n) | Medication change (%) | Mean medication (n) ± SE | Mean difference (n) | Medication change (%) | Mean medication (n) ± SE | Mean difference (n) | Medication change (%) | |
| Baseline (n = 53) | 2.5 (0.2) | – | – | 2.5 (0.2) | 2.6 (0.3) | ||||
| Day 1 (n = 53) | 1.7 (0.2) | − 0.8 | − 32.0 | 1.6 (0.3) | − 0.9 | − 36.0 | 1.9 (0.3) | − 0.7 | − 26.9 |
| Week 1 (n = 51) | 1.8 (0.2) | − 0.7 | − 28.0 | 1.7 (0.3) | − 0.8 | − 32.0 | 1.9 (0.3) | − 0.7 | − 26.9 |
| Month 1 (n = 52) | 1.8 (0.2) | − 0.7 | − 28.0 | 1.7 (0.3) | − 0.8 | − 32.0 | 2.0 (0.3) | − 0.6 | − 23.1 |
| Month 3 (n = 43) | 1.5 (0.2) | − 1.0 | − 40.0 | 1.4 (0.3) | − 1.1 | − 44.0 | 1.5 (0.3) | − 1.1 | − 42.3 |
| Month 6 (n = 53) | 1.5 (0.2) | − 1.0 | − 40.0 | 1.6 (0.3) | − 0.9 | − 36.0 | 1.3 (0.3) | − 1.3 | − 50.0 |
aReported are least squares means and associated standard errors from a mixed model for repeated measure analysis. Per Bonferroni pairwise comparison, the difference from baseline in mean medications is statistically significant at each follow-up visit (p < 0.05) except for month 1 (p = 0.100)