Table 4.

Individuals’ serum neutrophil elastase (NE) and C-reactive protein (CRP) concentrations

Parameters		Chronic periodontitis; ChP (n = 25)	Aggressive periodontitis; AgP (n = 17)	ChP/AgP p
Neutrophil elastase [ng/ml]	Baseline	10.9 (7.7/30.3)	36.0 (25.4/37.8)	0.002
median (lower/upper quartile)	12 weeks	18.8 (7.2/36.1)	33.9 (22.0/36.5)	0.075
Change baseline to 12 weeks		0.0 (− 1.4/5.9)	− 2.1 (− 4.6/− 0.6)	0.030
	60 months	14.3 (9.8/22.5)	22.4 (17.3/37.1)	0.006
Change baseline to 60 months		2.1 (− 6.6/11.1)	− 7.0 (− 20.8/10.2)	0.473
Change 12 weeks to 60 months		− 1.0 (− 21.1/7.9)	2.4 (− 17.9/9.8)	0.818
CRP [mg/dl]	Baseline	0.10 (0.08/0.16)	0.24 (0.14/0.48)	0.001
median (lower/upper quartile)	12 weeks	0.11 (0.07/0.22)	0.28 (0.14/0.45)	0.007
Change baseline to 12 weeks		0.01 (− 0.03/0.04)	0.0 (− 0.09/0.09)	0.778
	60 months	0.10 (0.06/0.31)	0.43 (0.25/0.93)	0.005
Change baseline to 60 months		− 0.02 (− 0.07/0.17)	0.13 (− 0.09/0.66)	0.522
Change 12 weeks to 60 months		0.01 (− 0.08/0.14)	0.21 (− 0.08/0.71)	0.324
CRP reduction ≥ 0.3 mg/dl [n]/frequency (%) baseline to 12 weeks		0 (0%)	3 (18%)	0.059
Baseline to 60 months [n]/frequency (%)		1 (4%)	3 (18%)	0.286
CRP < 0.1 mg/dl	Baseline	10 (40%)	0 (0%)	0.003
[n]/frequency (%)	12 weeks	11 (44%)	2 (12%)	0.027
	60 months	12 (48%)	2 (12%)	0.020
CRP 0.1 to 0.3 mg/dl [n] (%)	Baseline	13 (52%)	10 (59%)	0.663
[n]/frequency (%)	12 weeks	10 (40%)	7 (41%)	0.939
	60 months	7 (28%)	3 (18%)	0.490
CRP > 0.3 mg/dl [n] (%)	Baseline	2 (8%)	7 (41%)	0.019
[n]/frequency (%)	12 weeks	4 (16%)	8 (47%)	0.041
	60 months	6 (24%)	12 (70%)	0.003