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. 2018 Aug 13;470(12):1739–1751. doi: 10.1007/s00424-018-2190-4

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© The Author(s) 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 4 — More diluted urine in the hyperuricosuric kiKO mice. a KiKO mice display an increase urine volume compared to control mice. Values are means ± SD (n = 16, *p < 0.05). b Urine osmolality is not changed between control and kiKO mice. Values are means ± SD (n = 23). c Urine concentration test. After 9 and 23 h of water deprivation, both control and kiKO mice are able to concentrate their urine the same way, with significantly increased urine osmolality compared to baseline, but no difference between the two genotypes. Values are means ± SD (n = 10). d. Measurement of osmolality in the cortex and the papilla of control (white bars) and kiKO (black bars) mice did not show any difference between both genotypes. A significant increase of osmolality is measured in the papilla by comparison with the cortex, for both control and kiKO mice. Data are expressed as mOsm/l per mg of renal tissue. Values are means ± SD (n = 20, *p < 0.05)