Fig 7. E. chaffeensis TRP47 binds to noncoding RNA genes in the host cell.

(A) TRP47 targets include RNA-coding genes. When significant TRP47 binding peaks were submitted to BEDTools closest, 23% of peak-gene associations corresponded to RNA-coding genes. Of these, the majority were noncoding RNAs (66%) followed by microRNAs (16%), antisense RNAs (10%), pseudogenes (5%), small nucleolar RNAs (3%), and small nuclear RNAs (<1%). (B) A table of selected characterized noncoding RNA genes bound by TRP47 showing that many are involved cell proliferation or apoptosis and some are also bound by another ehrlichial TRP: NR_027181.1 [23], NR_029833.1 [24], NR_029608.1 [25], NR_126415.1 [26].