Table 1. Scores statistics, overall and by patient’s diagnosis.

		Mean, SD	Difference (95% CI)	P*, Cr. P**
VEGF-A	Nevus	1.26, 0.64	Ref.	0.868, 0.050
	MM	1.31, 1.31	0.05 (-0.23, 0.33)	0.723, 0.039
	Metastasis	1.22, 0.86	-0.04 (-0.37, 0.29)	0.821, 0.043
VEGF-B	Nevus	1.82, 0.93	Ref.	0.841, 0.043
	MM	1.83, 1.43	0.004 (-0.34, 0.35)	0.980, 0.050
	Metastasis	1.94, 1.22	0.11 (-0.29, 0.52)	0.583, 0.032
VEGF-C	Nevus	4.91, 2.76	Ref.	0.016, 0.021
	MM	5.73, 4.83	0.82 (-0.33, 1.97)	0.160, 0.021
	Metastasis	6.87, 4.36	1.96 (0.62, 3.30)	0.004, 0.011
VEGF-D	Nevus	3.91, 2.28	Ref.	0.697, 0.036
	MM	4.24, 3.17	0.33 (-0.43, 1.09)	0.396, 0.029
	Metastasis	4.08, 2.31	0.17 (-0.73, 1.06)	0.715, 0.036
VEGF-R1	Nevus	0.64, 0.35	Ref.	0.661, 0.029
	MM	0.73, 1.08	0.10 (-0.12, 0.31)	0.377, 0.025
	Metastasis	0.66, 0.58	0.02 (-0.23, 0.27)	0.882, 0.046
VEGF-R2	Nevus	10.75, 4.90	Ref.	<0.001, 0.007
	MM	12.84, 6.31	2.09 (0.39, 3.78)	0.016, 0.014
	Metastasis	15.10, 6.80	4.35 (2.36, 6.33)	<0.001, 0.004
VEGF-R3	Nevus	8.17, 4.17	Ref.	0.002, 0.014
	MM	9.35, 6.64	1.18 (-0.45, 2.81)	0.156, 0.018
	Metastasis	11.59, 6.31	3.42 (1.51, 5.33)	0.001, 0.007

CI: confidence interval, MM: malignant melanoma, P: p-value, SD: standard deviation

* P-values in italics are single p-values from one-way MANOVA analysis. Other p-values test the differences against a reference category for each score. The overall difference of the scores across different diagnoses is significant at p<0.001.

** Benjamini–Hochberg critical values for multiple comparisons with a false discovery rate of 0.05. A first set of tests was performed on the overall difference for each score; then a second sub-set of tests was done on the specific differences within each score. Results must be considered statistically significant (boldfaced) only when their p-values are lower than the corresponding critical values (Cr. P).