Table 2. Whole brain volume change over 5 years.

Pipeline		Multiple sclerosis	Normal controls	p-value (between groups)
SPM	Baseline BPF	0.741 (0.039)	0.790 (0.038)	0.001*
	Follow-up BPF	0.738 (0.039)	0.783 (0.045)	0.005*
	Change in BPF (p-value within group)	-0.003 (0.023) p = 0.63	-0.007 (0.026) p = 0.32	0.67
	Percent change in BPF	-0.33 (3.21)	-0.81 (3.24)	0.68
SIENA	PBVC	-0.79 (1.11)	-0.49 (1.11)	0.44

Data are shown as mean (standard deviation); BPF = brain parenchymal fraction; PBVC = percentage brain volume change between baseline and follow-up (a negative number indicates brain volume loss over time); SPM = statistical parametric mapping, v. 12; SIENA = structural image evaluation, using normalization, of atrophy, v. 5.0

*p<0.05