Table 3. Cerebral deep gray matter volume change over 5 years.
| Structure | FSL-FIRST | FreeSurfer | |||||
|---|---|---|---|---|---|---|---|
| MS | NC | p-value MS vs. NC |
MS | NC | p-value MS vs. NC |
||
| Thalamus | Baseline | 14.77 (1.41) | 15.96 (1.60) | 0.033* | 10.42 (1.21) | 11.90 (2.41) | 0.036* |
| Follow-up | 14.62 (1.34) | 15.78 (1.47) | 0.027* | 10.24 (1.26) | 11.69 (2.28) | 0.033* | |
| Change | -0.15 (0.73) p = 0.41 |
-0.18 (0.37) p = 0.066 |
0.89 | -0.19 (0.65) p = 0.27 |
-0.21 (0.56) p = 0.15 |
0.90 | |
| Percent change | -0.87 (5.54) p = 0.54 |
-1.06 (2.26) p = 0.080 | 0.90 | -1.61 (7.24) p = 0.39 | -1.56 (4.09) p = 0.15 | 0.98 | |
| Caudate | Baseline | 6.92 (1.14) | 7.66 (0.90) | 0.051 | 6.96 (1.15) | 7.34 (0.88) | 0.30 |
| Follow-up | 6.71 (0.90) | 7.53 (0.85) | 0.012* | 6.45 (0.90) | 7.30 (0.91) | 0.013* | |
| Change | -0.21 (0.50) p = 0.11 |
-0.12 (0.27) p = 0.091 |
0.53 | -0.51 (0.72) p = 0.012* |
-0.05 (0.28) p = 0.52 |
0.022* | |
| Percent change | -2.45 (7.43) p = 0.21 | -1.50 (3.35) p = 0.094 | 0.64 | -6.55 (9.05) p = 0.011* | -0.63 (3.94) p = 0.53 | 0.023* | |
| Putamen | Baseline | 10.04 (1.21) | 10.57 (1.39) | 0.26 | 9.86 (1.47) | 11.11 (1.37) | 0.019* |
| Follow-up | 9.74 (1.10) | 10.40 (1.14) | 0.10 | 9.82 (1.50) | 10.94 (1.34) | 0.034* | |
| Change | -0.30 (0.44) p = 0.014* |
-0.17 (0.54) p = 0.23 |
0.46 | -0.03 (0.87) p = 0.88 |
-0.16 (0.53) p = 0.23 |
0.61 | |
| Percent change | -2.84 (4.22) p = 0.017* | -1.28 (5.14) p = 0.33 | 0.36 | -0.00 (9.01) p = 0.99 | -1.37 (4.86) p = 0.28 | 0.60 | |
| Globus pallidus | Baseline | 2.98 (0.81) | 3.52 (0.42) | 0.023* | 5.84 (2.15) | 5.72 (2.20) | 0.87 |
| Follow-up | 2.78 (0.73) | 3.39 (0.44) | 0.007* | 5.63 (1.92) | 5.66 (2.16) | 0.96 | |
| Change | -0.20 (0.27) p = 0.010* |
-0.13 (0.19) p = 0.015* |
0.41 | -0.21 (0.37) p = 0.036* |
-0.05 (0.38) p = 0.060 |
0.24 | |
| Percent change | -5.86 (9.50) p = 0.026* | -3.65 (5.16) p = 0.013* | 0.42 | -2.13 (6.95) p = 0.24 | -0.57 (7.24) p = 0.76 | 0.54 | |
| Total DGM | Baseline | 34.71 (3.87) | 37.71 (3.76) | 0.033* | 33.09 (4.41) | 36.07 (3.30) | 0.039* |
| Follow-up | 33.84 (3.35) | 37.11 (3.40) | 0.010* | 32.15 (4.16) | 35.59 (3.21) | 0.014* | |
| Change | -0.87 (1.43) p = 0.028* |
-0.61 (1.08) p = 0.040* |
0.56 | -0.94 (1.87) p = 0.063 |
-0.47 (0.97) p = 0.068 |
0.38 | |
| Percent change | -2.29 (4.39) p = 0.054 | -1.50 (2.85) p = 0.052 | 0.55 | -2.62 (5.98) p = 0.10 | -1.28 (2.62) p = 0.070 | 0.42 | |
Data are shown as mean (standard deviation), with volume in ml, unless otherwise indicated; MS = multiple sclerosis; NC = normal controls; total DGM = cerebral subcortical deep gray matter = thalamus + caudate + putamen + globus pallidus; FSL-FIRST = FMRIB’s integrated registration & segmentation tool, v. 5.0
*p<0.05