Table 1. Model parameters: Baseline values, ranges, and distributions for Monte Carlo sensitivity analysis.

Variable	Value	Lower range	Upper Range	Reference	Distribution
Age	64	50	70	RESORCE	NA
Cost diarrhea	$81.60	$65.28	$97.92		gamma
Cost fatigue	0	0	0		gamma
Cost hand foot syndrome	$134.48	$107.58	161.38		gamma
Cost hypertension	$59.10	$47.28	$70.92		gamma
Duration diarrhea	5 days	-	-	Estimated	gamma
Duration fatigue	10 days	-	-	Estimated	gamma
Duration hand foot syndrome	14 days	-	-	Estimated	gamma
Duration hypertension	5 days	-	-	Estimated	gamma
Disutility diarrhea	-0.103	-0.082	-0.123	(12)	beta
Disutility fatigue	-0.115	-0.093	-0.139	(12)	beta
Disutility hand foot syndrome	-0.116	-0.093	-0.139	(12)	beta
Disutility hypertension	0	0	0
γ Placebo progression	0.86233	0.8	0.9	RESORCE	Triangular
γ Placebo survival	1.07166	1.05	1.09	RESORCE	Triangular
γ Regorafenib progression	0.92149	0.9	0.95	RESORCE	Triangular
γ Regorafenib survival	1.06134	1.06	1.07	RESORCE	Triangular
λ Placebo progression	0.4345	0.4	0.5	RESORCE	Triangular
λ Placebo survival	0.0775	0.06	0.08	RESORCE	Triangular
λ Regorafenib progression	0.21159	0.2	0.25	RESORCE	Triangular
λ Regorafenib survival	0.05389	0.03	0.07	RESORCE	Triangular
Incidence diarrhea placebo	0%	0%	0%	RESORCE	beta
Incidence diarrhea regorafenib	3%	2%	4%	RESORCE	beta
Incidence fatigue placebo	5%	4%	6%	RESORCE	beta
Incidence fatigue regorafenib	9%	8%	10%	RESORCE	beta
Incidence hand foot syndrome placebo	1%	0%	2%	RESORCE	beta
Incidence hand foot syndrome regorafenib	13%	11%	15%	RESORCE	beta
Incidence hypertension placebo	5%	4%	6%	RESORCE	beta
Incidence hypertension regorafenib	15%	13%	17%	RESORCE	beta
Discount rate	0.03	0	0.05	N/A
Utility of base	0.76	0.61	0.91	(24)	Normal
Utility of progression	0.68	0.54	0.82	(24)	Normal
Cost of Regorafenib 120 MG ($ per month)	11,389	N/A		GoodRX
Cost of Regorafenib 144MG ($ per month)	13,667	N/A		GoodRX
Cost of Regorafenib 160 MG ($ per month)	15,186	12,149	15,186	GoodRX	Triangular