FIG. 1.

(a) An example of growth in a truncated rat heart under pulmonary hypertension. (left) Normal state, (right) hypertrophic state. [Reproduced with permission from Hirata et al., BioMed Res. Int. 2015, 1–10 (2015). Copyright 2015 Author(s), licensed under a Creative Commons Attribution 3.0 Unported License.)].¹⁵ (b) Schematic biventricular configurations in various stages of adaptation to a sustained, overload pressure. (left) Homeostatic state, (middle) hypertrophy-triggered state, (right) RV-remodeled state. S_w, wall stress; $S_w^h$, homeostatic value; $S_w^{\mathit{\text{trig}}}$, trigger value.