Table 2. wAIHA baseline characteristics in the whole cohort and comparison between patients with or without VTE.
| Overall AIHA n = 48 |
AIHA without VTE n = 37 |
AIHA with VTE n = 11 |
p-value | ||
|---|---|---|---|---|---|
| Epidemiology at wAIHA diagnosis | Number of females; n (%) | 24 (50) | 19 (51. 4) | 5 (45.5) | 0.73 |
| Median age | 65 [44–78] | 64.79 [32.9] | 63.43 [39] | 0.79 | |
| Primary AIHA; n (%) | 23 (48) | 16 (43.2) | 7 (63.6) | 0.31 | |
| Median Padua score | 1 [0–3.75] | 1 [0–3.5] | 2 [0–3] | 0.97 | |
| Median Padua score (at VTE diagnosis) | - | - | 3 [0–5] | 0.56 | |
| Number of deaths; n (%) | 8 (16.6) | 6 (16.2) | 2 (18.2) | 1 | |
| Antiplatelet therapy; n (%) | 7 (14.3) | 5 (13.5) | 1 (9.1) | 0.49 | |
| VKA; n (%) | 14 (28.6) | 7 (18.9) | 1 (9.1) | 0.40 | |
| Clinical features at wAIHA diagnosis | Dyspnea; n (%) | 17 (36.1) | 12 (32.1) | 6 (54) | 0.30 |
| Icterus; n (%) | 8 (16.2) | 2 (7.1) | 5 (44.4) | 0.02 | |
| Biological parameters at wAIHA diagnosis | Hemoglobin (g/L) | 73 [63–90] | 72 [63–88.5] | 74 [56–89] | 0.90 |
| Reticulocytes (x109/L) | 182 [121–287] | 157.5 [114–249] | 287.9 [147–341] | 0.06 | |
| Platelets (x109/L) | 237 [155–339] | 228 [155–310] | 283 [165–364] | 0.56 | |
| Leukocytes (x109/L) | 7.9 [5.6–12.35] | 7.3 [5.4–10.5] | 11.9 [8.6–18.1] | 0.02 | |
| LDH level >normal range; n (%) | 37 (77) | 28 (75.7) | 9 (81.8) | 1 | |
| Total bilirubin (μmol/L) | 33.5 [22.5–45] | 31 [25–39] | 41 [32–47.5] | 0.04 | |
| Total bilirubin≥40; n (%) | 15 (31) | 8 (21.6) | 7 (63.6) | 0.02 | |
| Free bilirubin (μmol/L) | 32 [26.3–41] | 31 [24.5–39.5] | 39.5 [31.5–47.2] | 0.09 | |
| Free bilirubin ≥35; n (%) | 15 (31) | 9 (24.3) | 6 (54.5) | 0.07 | |
| CRP (mg/L) | 10.3 (3.7–25.3) | 9.8 (4.5–25.4) | 10.9 (3–25.9) | 0.9 | |
| CRP (mg/L) at VTE diagnosis | - | - | 13.5 (6.9–39.8) | 0.5 | |
| CH50 <normal range 22/48; n (%) | 4 (9.1) | 2 (5.4) | 0 (0) | 0.52 | |
| Low C3 <normal range 26/48; n (%) | 12 (24) | 2 (5.4) | 3 (27.3) | 0.10 | |
| Low C4 <normal range 26/48; n (%) | 12 (24) | 5 (13.5) | 1 (9.1) | 0.68 | |
| Abnormality of lymphoid lineage on bone marrow aspirate 27/48; n (%) | 11 (23.1) | 8 (22.7) | 3 (25) | 0.68 | |
| Imaging | Splenomegaly 36/48; n (%) | 12 (26.7) | 9 (25) | 3 (37.5) | 0.39 |
| Hepatomegaly 36/48; n (%) | 7 (15.6) | 4 (10.7) | 3 (37.5) | 0.11 | |
| Adenopathy 36/48; n (%) | 7 (15.6) | 4 (10.7) | 3 (37.5) | 0.11 |
CRP: C reactive protein, LDH: lactate dehydrogenase, VKA: vitamin K antagonists. Quantitative variables are reported as medians [interquartile rate]. Qualitative variables are reported as numbers (frequencies); n (%).