Figure 2.

A Number of sequences forming pseudoknots (Ps+), or ambivalent sequences (Amb+, sequences predicted to assume both pseudoknot and non-pseudoknot conformations of < 1kcal/mol difference between the most stable non-pseudoknot conformation and the next less stable pseudoknot conformation), in sequences predicted to form G4s (G4+, right) or without G4s (G4-, left) among the epigenetic clock sequence ensemble (± 50 nt from clock CpGs, G50). B Number of sequences containing G-quadruplexes in different sequence sizes and the corresponding ratio of G4+/G4- sequences. P values obtained by chi-squared test.