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. 2018 Sep 29;13(8):808–821. doi: 10.1080/15592294.2018.1514232

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© 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 3. — Dot plots indicating the median CpG methylation and methylation variance by CpG in: A. Young individuals with respect to the propensity of the surrounding sequence (CpG ± 50 nt) to form G4s (G4+) and pseudoknots (Ps), or ambivalent sequences (Amb+), B. Young (black) and old (red) individuals with respect to the relative the positions of CpG and G4s in the surrounding sequence (CpG ± 50 nt), C. Young individuals with respect to the relative folding stability and propensity of the surrounding sequence (± 50 nt) to form G4s (ΔGl < 16.35 kcal/mol, ΔGh > 16.35 kcal/mol), D. Young individuals with respect to the combined presence of G4 and pseudoknots in the surrounding sequence (CpG ± 50 nt). E. Variance of methylation by CpG relative to the sequence propensity to form G4s, identified in different sequence lengths (± 50 nt and ± 100 nt). Statistically significant differences by Student’s t-test are shown by *.