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. 2018 Sep 29;13(8):808–821. doi: 10.1080/15592294.2018.1514232

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© 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 7. — Characteristics of the 1500 nt regions upstream transcription start sites (TSS1500). A. Frequency of G4, Pseudoknots, ambivalent motifs and their combinations (P values obtained by chi-squared test) in sequences predicted (black) or not (striped) to be loci of transcription initiation. B. Dot plots of median methylation (black) and methylation variance by CpG (green) among young individuals in TSS sequences with ‘open’ or ‘closed’ conformation. Statistically significant differences by Student’s t-test are shown by *.