Table 1.
Median methylation (beta values) differences between young and old subjects relative to the presence of G4, RNA co-transcriptional structures and stability and the presence of tentative splice sites.
| Median methylation decrease x102 (sequences) | Median methylation increase x102 (sequences) | p* | |
|---|---|---|---|
| All sequences | 4.66 (148) | 2.86 (177) | 0.007 |
| G4- | 4.2 (99) | 2.7(102) | 0.01 |
| G4-/ΔGh | 3.93(60) | 2.7 (67) | 0.13 |
| G4-/ΔGl | 4.73(38) | 2.69(35) | 0.017 |
| G4-/Ps+ or Amb+ | 4.31 (70) | 2.96 (62) | 0.075 |
| G4-/Ps-/Amb- | 4.07(29) | 2.3(40) | 0.069 |
| G4+ | 5.5(49) | 3.09(75) | 0.099 |
| G4+/Ps-/Amb- | 3.14 (20) | 3.56 (43) | 0.709 |
| G4+/Ps+ or Amb+ | 7.1(29) | 2.4(32) | 0.085 |
| CpG< median average | 5.45 (92) | 3.32 (69) | 0.003 |
| CpG> median average | 4.92 (21) | 3.71 (75) | 0.21 |
*Student’s t-test
ΔGh > 16.35 kcal/mol; ΔGl < 16.35 kcal/mol